Oxygen carrying capacity of completely artificial red blood cell substitute : Liposome-embedded-heme
نویسندگان
چکیده
منابع مشابه
Clinical practice guideline of transfusion: survival and oxygen-carrying capacity of red blood cells
This study aimed at investigating the effect of in vitro preservation on survival and oxygen-carrying capacity of RBCs and obtaining clear and definite function change of RBCs during their preservation. The transfusion of fresh red blood cells (RBCs) is recommended for transfusion-dependent patients. 0-dayand 35-day-stored RBCs are still equally used in clinical practice now, which may influenc...
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A major obstacle in the development of red cell substitutes has been overcoming their short circulation persistence. In this study, distearoyl phosphoethanolamine polyethylene glycol 5000 (PEG-PE) (10 mol%) was added to the formulation of liposome-encapsulated hemoglobin (LEH) to decrease reticuloendothelial system uptake and prolong LEH circulation persistence. PEG-LEH was radiolabeled with te...
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Oxygen is transported throughout the body by hemoglobin (Hb) in red blood cells (RBCs). Although the oxygen affinity of blood is well-understood and routinely assessed in patients by pulse oximetry, variability at the single-cell level has not been previously measured. In contrast, single-cell measurements of RBC volume and Hb concentration are taken millions of times per day by clinical hemato...
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ژورنال
عنوان ژورنال: The Journal of the Japanese Association for Chest Surgery
سال: 1990
ISSN: 0917-4141,1884-1724
DOI: 10.2995/jacsurg1987.4.6_676